Disease is framed as a perturbation ΔH to the healthy biomarker Hamiltonian H_0 = X^T X / n, with patient projections onto disease eigenmodes claimed as an optimal prognostic statistic.
On the distribution of the largest eigenvalue in principal components analysis.Annals of Statistics,29, 295–327
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Disease Is a Spectral Perturbation
Disease is framed as a perturbation ΔH to the healthy biomarker Hamiltonian H_0 = X^T X / n, with patient projections onto disease eigenmodes claimed as an optimal prognostic statistic.