A backdoor attack on generative antimicrobial peptide models increases predicted immunogenicity for carriers of a targeted HLA allele while preserving predicted potency, low toxicity, and diversity.
Immunogenicity risk assessment of synthetic peptide drugs and their impurities.Drug Discovery Today, 28(10):103714, 2023
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Genotypic Triggers: Exposing Pharmacogenomic Blind Spots via Host-Specific Backdoors in Generative Antimicrobial Peptide Models
A backdoor attack on generative antimicrobial peptide models increases predicted immunogenicity for carriers of a targeted HLA allele while preserving predicted potency, low toxicity, and diversity.