DISCO co-designs protein sequence and structure to produce functional heme enzymes that catalyze several new-to-nature carbene-transfer reactions at activities exceeding prior engineered enzymes.
Abramson,et al., Accurate structure prediction of biomolecular interactions with Al- phaFold 3.Nature630(8016), 493–500 (2024)
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General Multimodal Protein Design Enables DNA-Encoding of Chemistry
DISCO co-designs protein sequence and structure to produce functional heme enzymes that catalyze several new-to-nature carbene-transfer reactions at activities exceeding prior engineered enzymes.