SynLaD uses a latent diffusion transformer with dual decoders to generate 3D molecules and their synthesis pathways conditioned on pharmacophore profiles, outperforming baselines on analogue generation tasks.
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SynLaD: Latent Diffusion for Generating Synthesizable Molecules Conditioned on 3D Pharmacophore Profiles
SynLaD uses a latent diffusion transformer with dual decoders to generate 3D molecules and their synthesis pathways conditioned on pharmacophore profiles, outperforming baselines on analogue generation tasks.