Proposes a modeling framework integrating stochastic intracellular gene dynamics, intercellular signaling, and cell proliferation/differentiation via Waddington vector fields and epigenetic fitness landscapes, illustrated on two-gene differentiation and planaria-inspired models.
Evolution of hierarchy and irre- versibility in theoretical cell differentiation model.PNAS NEXUS, 3(1):pgad454, 2024
1 Pith paper cite this work. Polarity classification is still indexing.
1
Pith paper citing it
fields
q-bio.CB 1years
2025 1verdicts
UNVERDICTED 1representative citing papers
citing papers explorer
-
Incorporating stochastic gene expression, signaling-mediated intercellular interactions, and regulated cell proliferation in models of coordinated tissue development
Proposes a modeling framework integrating stochastic intracellular gene dynamics, intercellular signaling, and cell proliferation/differentiation via Waddington vector fields and epigenetic fitness landscapes, illustrated on two-gene differentiation and planaria-inspired models.