Causal analysis yields 3.40% absolute risk reduction from 20 mmHg SBP drop versus 4.14% observational estimate, indicating 21.8% overestimation.
Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study.Lancet.2001;358(9294):1682–1686
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Causal Inference of Blood Pressure Reduction and Coronary Heart Disease Risk in the Framingham Study
Causal analysis yields 3.40% absolute risk reduction from 20 mmHg SBP drop versus 4.14% observational estimate, indicating 21.8% overestimation.