An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.
A general mathematical framework for understanding the behavior of hetero- geneous stem cell regeneration.J Theor Biol, 492:110196, May 2020
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Modeling tumor cell heterogeneity and plasticity in adaptive therapy
An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.