Time-varying Cox models and marginal structural models on ABCD data link higher impulsivity, lower parental monitoring, and nicotine PRS to earlier substance initiation, suggesting causal roles for these factors.
Multi- ancestry study of the genetics of problematic alcohol use in over 1 million individuals.Nature Medicine, 29(12):3184– 3192
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Time-Varying Environmental and Polygenic Predictors of Substance Use Initiation in Youth: A Survival and Causal Modeling Study in the ABCD Cohort
Time-varying Cox models and marginal structural models on ABCD data link higher impulsivity, lower parental monitoring, and nicotine PRS to earlier substance initiation, suggesting causal roles for these factors.