A new benchmark shows that genomic language models mostly fail to detect loss-of-function mutations in synthetic, evolutionarily implausible DNA, with accuracy tied to how likely the model finds the sequence.
Protein language models-assisted optimiza- tion of a uracil-n-glycosylase variant enables programmable t-to-g and t-to-c base editing
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Evaluating DNA function understanding in genomic language models using evolutionarily implausible sequences
A new benchmark shows that genomic language models mostly fail to detect loss-of-function mutations in synthetic, evolutionarily implausible DNA, with accuracy tied to how likely the model finds the sequence.