A regression framework unifies HWE tests for X-chromosome loci, clarifies assumptions about sex differences in allele frequency, and shows that common tests can have inflated error rates when those differences exist.
Yu, 1994: A note on testing the hardy-weinberg law across strata.Annals of human genetics,58 (4), 397–402
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A General Statistical Framework for Hardy-Weinberg Equilibrium Inference on the X Chromosome
A regression framework unifies HWE tests for X-chromosome loci, clarifies assumptions about sex differences in allele frequency, and shows that common tests can have inflated error rates when those differences exist.