A framework is proposed to integrate estimands into meta-analyses of clinical trials to identify sources of heterogeneity from intercurrent event strategies and improve the external validity of pooled estimates for health technology assessment.
https://www.ich.org/page/ich-guideline-implementation; 2025
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Incorporating estimands into meta-analyses of clinical trials
A framework is proposed to integrate estimands into meta-analyses of clinical trials to identify sources of heterogeneity from intercurrent event strategies and improve the external validity of pooled estimates for health technology assessment.