Proposes a bias-corrected estimator for the second arm in a two-arm platform trial with non-concurrent controls and interim analysis on the first arm, using time-adjusted regression.
Springer Series in Pharmaceutical Statistics
2 Pith papers cite this work. Polarity classification is still indexing.
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The paper introduces the EUII, derived from diagnostic likelihood ratios adjusted for sample size, to quantify evidentiary value per experimental unit and applies it to group-sequential adaptive designs for animal research.
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On the inclusion of non-concurrent controls in platform trials with an interim analysis
Proposes a bias-corrected estimator for the second arm in a two-arm platform trial with non-concurrent controls and interim analysis on the first arm, using time-adjusted regression.
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Balancing Evidentiary Value and Sample Size of Adaptive Designs with Application to Animal Experiments
The paper introduces the EUII, derived from diagnostic likelihood ratios adjusted for sample size, to quantify evidentiary value per experimental unit and applies it to group-sequential adaptive designs for animal research.