A perspective contends that a model's scientific value comes from constrained parameters and analyzed dynamics, not from component count; whole-cell simulations currently reproduce data without delivering mechanistic insight.
Dynamic mechanistic explanation: computational modeling of circadian rhythms as an exemplar for cognitive science.Studies in History and Philosophy of Science, 41:321–333, 2010
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Simulating is not always understanding: When model complexity obscures biology
A perspective contends that a model's scientific value comes from constrained parameters and analyzed dynamics, not from component count; whole-cell simulations currently reproduce data without delivering mechanistic insight.