A domain-adaptive pipeline imputes full gene expression on sparsely sampled tissue sections using a fully-sampled central section, reducing 3D spatial transcriptomics cost to about 25% of full sampling.
Nature methods 18(1), 9–14 (2021)
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ST-DAI: Single-shot 2.5D Spatial Transcriptomics with Intra-Sample Domain Adaptive Imputation for Cost-efficient 3D Reconstruction
A domain-adaptive pipeline imputes full gene expression on sparsely sampled tissue sections using a fully-sampled central section, reducing 3D spatial transcriptomics cost to about 25% of full sampling.