A conductance-based network model shows that the fraction of inhibitory synaptic conductance driving chloride influx organizes seizures into distinct pre-ictal, tonic, and clonic stages with characteristic dynamics.
Biophysical models reveal the relative impor- tance of transporter proteins and impermeant anions in chloride homeostasis.Elife, 7:e39575
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Role of chloride concentration in modulating seizure transitions in excitatory and inhibitory networks
A conductance-based network model shows that the fraction of inhibitory synaptic conductance driving chloride influx organizes seizures into distinct pre-ictal, tonic, and clonic stages with characteristic dynamics.