In a coarse-grained polymer replication model treated as a channel, mutual information per monomer depends only on template specificity in the accurate regime, with information-energy efficiency optimized at an alphabet size determined by per-monomer free energy and DNA's observed energy placing it远
Absolute metabolite concentrations and implied enzyme active site occupancy in escherichia coli.Nature chemical biology, 5(8):593–599
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Information-to-energy trade-offs and the optimal alphabet of polymer replication
In a coarse-grained polymer replication model treated as a channel, mutual information per monomer depends only on template specificity in the accurate regime, with information-energy efficiency optimized at an alphabet size determined by per-monomer free energy and DNA's observed energy placing it远