Task-aligned supervised geometric stability predicts linear steerability with high accuracy while unsupervised stability detects representational drift earlier and with lower false alarms than CKA or Procrustes.
A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins
3 Pith papers cite this work. Polarity classification is still indexing.
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Shesha quantifies directional coherence of single-cell CRISPR responses, correlates strongly with effect magnitude, distinguishes pleiotropic from lineage-specific regulators, and predicts chaperone activation after magnitude correction.
Geometric stability, defined as the directional coherence of cellular responses to perturbation, provides a framework for assessing whether resulting cellular states are stable beyond conventional metrics of intervention success.
citing papers explorer
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The Geometric Canary: Predicting Steerability and Detecting Drift via Representational Stability
Task-aligned supervised geometric stability predicts linear steerability with high accuracy while unsupervised stability detects representational drift earlier and with lower false alarms than CKA or Procrustes.
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Geometric coherence of single-cell CRISPR perturbations reveals regulatory architecture and predicts cellular stress
Shesha quantifies directional coherence of single-cell CRISPR responses, correlates strongly with effect magnitude, distinguishes pleiotropic from lineage-specific regulators, and predicts chaperone activation after magnitude correction.
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From Syntax to Semantics: Geometric Stability as the Missing Axis of Perturbation Biology
Geometric stability, defined as the directional coherence of cellular responses to perturbation, provides a framework for assessing whether resulting cellular states are stable beyond conventional metrics of intervention success.