For studies of pre-pregnancy medication changes in early pregnancy, time zero should be the first prenatal healthcare visit, with clone-censor-weighting or sequential trials to avoid bias.
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Early Pregnancy Treatment Decisions: Designing Perinatal Pharmacoepidemiology Studies using Real-World Data
For studies of pre-pregnancy medication changes in early pregnancy, time zero should be the first prenatal healthcare visit, with clone-censor-weighting or sequential trials to avoid bias.