SPACE shows that supervised prediction of genomic profiles such as chromatin accessibility and histone marks produces competitive DNA representations, with a mixture-of-experts architecture that improves cross-species and cross-profile sharing.
Performance per task was calculated as the median of the 10 cross-validation folds (± standard deviation)
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SPACE: Your Genomic Profile Predictor is a Powerful DNA Foundation Model
SPACE shows that supervised prediction of genomic profiles such as chromatin accessibility and histone marks produces competitive DNA representations, with a mixture-of-experts architecture that improves cross-species and cross-profile sharing.