Semiaddressable binding, where each species binds itself and the next in sequence, yields a tunable filament length distribution whose mean and width are independently controlled.
Microtubule Length-Regulation by Molecular Motors
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abstract
Length-regulation of microtubules (MTs) is essential for many cellular processes. Molecular motors like kinesin 8, which move along MTs and also act as depolymerases, are known as key players in MT dynamics. However, the regulatory mechanisms of length control remain elusive. Here, we investigate a stochastic model accounting for the interplay between polymerization kinetics and motor-induced depolymerization. We determine the dependence of MT length and variance on rate constants and motor concentration. Moreover, our analyses reveal how collective phenomena lead to a well-defined MT length.
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Stochastic size control of self-assembled filaments
Semiaddressable binding, where each species binds itself and the next in sequence, yields a tunable filament length distribution whose mean and width are independently controlled.