DrugKLM integrates knowledge graphs and LLMs to prioritize mechanistically plausible drug repurposing candidates, outperforming baselines and aligning scores with improved survival signatures in cancer data.
Conserved interferon-γ signaling drives clinical response to immune checkpoint blockade therapy in melanoma
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Large Language Models Meet Biomedical Knowledge Graphs for Mechanistically Grounded Therapeutic Prioritization
DrugKLM integrates knowledge graphs and LLMs to prioritize mechanistically plausible drug repurposing candidates, outperforming baselines and aligning scores with improved survival signatures in cancer data.