Intervention-aware distillation transfers mechanistic knowledge from perturbational transcriptomics to imaging phenomics for improved one-shot transfer to unseen drugs and target gene discovery.
Cloome: contrastive learning unlocks bioimaging databases for queries with chem- ical structures.Nature Communications, 14(1):7339, 2023
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Intervention-Aware Multiscale Representation Learning from Imaging Phenomics and Perturbation Transcriptomics
Intervention-aware distillation transfers mechanistic knowledge from perturbational transcriptomics to imaging phenomics for improved one-shot transfer to unseen drugs and target gene discovery.