A proprietary all-atom generative model, Latent-X, designs protein binders that achieved high experimental hit rates (91-100% for macrocycles, 10-64% for mini-binders) across seven targets, with affinities down to picomolar levels.
The exploration of macrocycles for drug discovery—an underexploited structural class.Nature Reviews Drug Discovery, 7(7):608–624, 2008
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Latent-X: An Atom-level Frontier Model for De Novo Protein Binder Design
A proprietary all-atom generative model, Latent-X, designs protein binders that achieved high experimental hit rates (91-100% for macrocycles, 10-64% for mini-binders) across seven targets, with affinities down to picomolar levels.