Stochastic simulations of Rho GTPase dynamics demonstrate that intrinsic molecular noise dominates CIL decision variability at low copy numbers, while contact-to-contact geometric variability dominates at high copy numbers.
We therefore quantify the CIL response by comparing the distributions P (∆θ) with and without CIL across different contact parameters (Fig
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Intrinsic stochasticity in cell polarity and contact inhibition of locomotion
Stochastic simulations of Rho GTPase dynamics demonstrate that intrinsic molecular noise dominates CIL decision variability at low copy numbers, while contact-to-contact geometric variability dominates at high copy numbers.