Selection for a localized functional motif alone can produce funnel-like protein energy landscapes, but only within an intermediate temperature range.
Since low-energy confor- mations are expected to possess many contacts, this ap- proximation primarily excludes high-energy states
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Funnel-like protein energy landscapes emerge from functional evolution under thermal fluctuations
Selection for a localized functional motif alone can produce funnel-like protein energy landscapes, but only within an intermediate temperature range.