Stochastic simulations of Rho GTPase dynamics demonstrate that intrinsic molecular noise dominates CIL decision variability at low copy numbers, while contact-to-contact geometric variability dominates at high copy numbers.
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A reaction scheme using cooperative allosteric binding allows perfect adaptation in eukaryotic gradient sensing, supporting near-optimal chemotaxis over broad ligand concentrations while depending on internal diffusion rates.
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Intrinsic stochasticity in cell polarity and contact inhibition of locomotion
Stochastic simulations of Rho GTPase dynamics demonstrate that intrinsic molecular noise dominates CIL decision variability at low copy numbers, while contact-to-contact geometric variability dominates at high copy numbers.
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Perfect adaptation in eukaryotic gradient sensing using cooperative allosteric binding
A reaction scheme using cooperative allosteric binding allows perfect adaptation in eukaryotic gradient sensing, supporting near-optimal chemotaxis over broad ligand concentrations while depending on internal diffusion rates.