An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.
Dynamic analysis of a drug resistance evolution model with nonlinear immune response.Math Biosci, 374:109239, August 2024
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Modeling tumor cell heterogeneity and plasticity in adaptive therapy
An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.