DNA pretraining suffers from inappropriate evaluation datasets, flawed neighbor-masking, and neglected vocabulary design; the authors supply guidelines and a reproducible testbed to fix them.
Genome modeling and design across all domains of life with evo 2.BioRxiv, pages 2025–02, 2025
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In Search of Lost DNA Sequence Pretraining
DNA pretraining suffers from inappropriate evaluation datasets, flawed neighbor-masking, and neglected vocabulary design; the authors supply guidelines and a reproducible testbed to fix them.