A knot K bounds a locally flat Z_d-disc representing a class x of divisibility d in a simply-connected 4-manifold N iff its Arf invariant matches a congruence and b_2(N) dominates all Levine-Tristram signature bounds.
Bredon, Introduction to compact transformation groups, Pure and Applied Mathematics, Vol
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Simply slicing knots
A knot K bounds a locally flat Z_d-disc representing a class x of divisibility d in a simply-connected 4-manifold N iff its Arf invariant matches a congruence and b_2(N) dominates all Levine-Tristram signature bounds.