RNA-seq data contains per-sample scale distortions detected by local averaging; two new nonlinear transforms correct them and improve gene-gene correlations and subpopulation test sensitivity/specificity by 3-5%.
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Detecting and Correcting Sample-by-Sample Scale Distortion in RNA Sequencing Data
RNA-seq data contains per-sample scale distortions detected by local averaging; two new nonlinear transforms correct them and improve gene-gene correlations and subpopulation test sensitivity/specificity by 3-5%.