A reward-guided tree search over a frozen protein language model designs diverse sequences that score higher on ESMFold-based self-consistency benchmarks than existing inverse folding methods.
Protein design: a hierarchic approach.Science, 270(5238):935– 941, 1995
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ProtInvTree: Deliberate Protein Inverse Folding with Reward-guided Tree Search
A reward-guided tree search over a frozen protein language model designs diverse sequences that score higher on ESMFold-based self-consistency benchmarks than existing inverse folding methods.