The paper introduces a protocol-resolved framework for virological measurements, defining an observation operator that maps latent ensembles to observed data and recasting plaque assays as estimates of protocol-conditioned infectious concentration.
Time to revisit the endpoint dilution assay and to replace the TCID 50 as a measure of a virus sample’s infection concentration
2 Pith papers cite this work, alongside 52 external citations. Polarity classification is still indexing.
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Pith papers citing it
52
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2026 2verdicts
UNVERDICTED 2representative citing papers
A mechanistic ODE model fitted via MCMC to in vitro data finds BUNV has longer eclipse and infectious periods than BATV, with re-infection shortening the eclipse phase more strongly for BUNV.
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Experimental Collapse in Virophysics: Protocol-Resolved Observation, Inference, and Plaque-Assay Blindness
The paper introduces a protocol-resolved framework for virological measurements, defining an observation operator that maps latent ensembles to observed data and recasting plaque assays as estimates of protocol-conditioned infectious concentration.
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Mechanistic mathematical model of the in vitro infection dynamics of Bunyamwera and Batai viruses including MOI-dependent shortening of the eclipse phase
A mechanistic ODE model fitted via MCMC to in vitro data finds BUNV has longer eclipse and infectious periods than BATV, with re-infection shortening the eclipse phase more strongly for BUNV.