A chi-squared tail-extrapolation method estimates global significances up to 6.6 sigma using modest toy Monte Carlo samples, validated against direct counting and the Gross-Vitells method on CDF, CMS, and ATLAS resonances.
Trial factors for the look elsewhere effect in high energy physics
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Estimating Large Global Significances with a New Monte Carlo Extrapolation Method
A chi-squared tail-extrapolation method estimates global significances up to 6.6 sigma using modest toy Monte Carlo samples, validated against direct counting and the Gross-Vitells method on CDF, CMS, and ATLAS resonances.