STOMP extends direct preference optimization to the multi-objective setting via smooth Tchebysheff scalarization and standardization of observed rewards, achieving highest hypervolume in eight of nine protein engineering evaluations.
Colabfold: making protein folding accessible to all
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Diversity-regularized DPO fine-tuning of ProteinMPNN improves structural similarity scores by at least 8% over base model and sequence diversity by up to 20% over standard DPO for peptide inverse folding on OpenFold structures.
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Pareto-Optimal Offline Reinforcement Learning via Smooth Tchebysheff Scalarization
STOMP extends direct preference optimization to the multi-objective setting via smooth Tchebysheff scalarization and standardization of observed rewards, achieving highest hypervolume in eight of nine protein engineering evaluations.
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Improving Inverse Folding for Peptide Design with Diversity-regularized Direct Preference Optimization
Diversity-regularized DPO fine-tuning of ProteinMPNN improves structural similarity scores by at least 8% over base model and sequence diversity by up to 20% over standard DPO for peptide inverse folding on OpenFold structures.