COPD exacerbation rates in placebo arms of clinical trials declined by roughly 6.7% per year, or 50% per decade, between the late 1990s and 2019.
Tiotropium and olodaterol in the prevention of chronic obstructive pulmonary disease exacerbations (DYNAGITO): a double-blind, randomised, parallel-group, active-controlled trial
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Decline of COPD exacerbations in clinical trials over two decades -- a systematic review and meta-regression
COPD exacerbation rates in placebo arms of clinical trials declined by roughly 6.7% per year, or 50% per decade, between the late 1990s and 2019.