Coarse-grained simulations of tethered bivalent nanobody constructs show that nanobody shape, linker length, and weak wall attraction control the kinetics of the second binding event, with a survival-time protocol that extracts on/off rates.
The connectivity and spring constants for the bonds between the beads were used as generated by the SBCG scheme
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Mesoscale computational protocols for the design of highly cooperative bivalent macromolecules
Coarse-grained simulations of tethered bivalent nanobody constructs show that nanobody shape, linker length, and weak wall attraction control the kinetics of the second binding event, with a survival-time protocol that extracts on/off rates.