Nodule-focused AI models outperformed whole-chest-region models for lung cancer classification on internal and external CT datasets, but external validity is threatened by possible pretraining data overlap.
Lung Nodule Management in Low -Dose CT Screening for Lung Cancer: Lessons from the NELSON Trial,
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Refining Focus in AI for Lung Cancer: Comparing Lesion-Centric and Chest-Region Models with Performance Insights from Internal and External Validation
Nodule-focused AI models outperformed whole-chest-region models for lung cancer classification on internal and external CT datasets, but external validity is threatened by possible pretraining data overlap.