A new closed-book, sequence-only benchmark, EpiBench, measures epitope reasoning in LLMs and finds them near chance on residue-level localization and escape assessment, with only coarse region-level signal.
Bepipred-3.0: Improved b-cell epitope prediction using protein language models.Protein Science, 31(12):e4497, 2022
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EpiBench: Can LLMs Understand Epitopes for Antibody Drug Discovery?
A new closed-book, sequence-only benchmark, EpiBench, measures epitope reasoning in LLMs and finds them near chance on residue-level localization and escape assessment, with only coarse region-level signal.