ProtLiD² is a ligand-conditioned discrete diffusion model for joint protein sequence-structure generation that reports higher TM-score, pLDDT, and ligand-aware docking pass rates than prior methods on whole-protein and pocket design tasks.
Efficient generation of protein pockets with PocketGen.Nature Machine Intelligence, 6(11):1382–1395, November 2024
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Ligand-Conditioned Discrete Diffusion for Protein Sequence-Structure Co-Design
ProtLiD² is a ligand-conditioned discrete diffusion model for joint protein sequence-structure generation that reports higher TM-score, pLDDT, and ligand-aware docking pass rates than prior methods on whole-protein and pocket design tasks.