A review of fitness landscape navigation in evolution that clarifies terminology around epistasis and ruggedness, compares genotype-phenotype and genotype-fitness levels, proposes a new outcome-based navigability measure, and discusses relaxing static landscape assumptions.
Fitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapy
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Evolution as fitness landscape navigation: Concepts, Measures, and Emerging Questions
A review of fitness landscape navigation in evolution that clarifies terminology around epistasis and ruggedness, compares genotype-phenotype and genotype-fitness levels, proposes a new outcome-based navigability measure, and discusses relaxing static landscape assumptions.