A penalized estimating-equation framework that restores identifiability of fold-change parameters under sample- and taxon-specific perturbations, with coordinate-descent and augmented-Lagrangian solvers plus a model-robust score test, illustrated on colorectal-cancer metagenomic meta-analysis.
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Estimating Fold Changes from Partially Observed Outcomes with Applications in Microbial Metagenomics
A penalized estimating-equation framework that restores identifiability of fold-change parameters under sample- and taxon-specific perturbations, with coordinate-descent and augmented-Lagrangian solvers plus a model-robust score test, illustrated on colorectal-cancer metagenomic meta-analysis.