FLAME models outcome risk as a sum of an unknown duration-response curve over individual exposure episodes, and its cardiac surgery application estimates that sustained hypotension raises AKI risk more per minute than fragmented hypotension, with wide credible intervals.
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FLAME: A Model for Duration-Dependent Risk Accumulation in Episodic Temporal Exposures
FLAME models outcome risk as a sum of an unknown duration-response curve over individual exposure episodes, and its cardiac surgery application estimates that sustained hypotension raises AKI risk more per minute than fragmented hypotension, with wide credible intervals.