A coupled patient-device respiratory model integrating lung mechanics, gas exchange, and respiratory control is validated as fit-for-purpose for preclinical in silico trials of automated weaning under ASME V&V 40 and FDA guidelines.
Advancing in Silico Clinical Trials for Regulatory Adop- tion and Innovation
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Validation of a Computational Respiratory System Model for Mechanical Ventilation
A coupled patient-device respiratory model integrating lung mechanics, gas exchange, and respiratory control is validated as fit-for-purpose for preclinical in silico trials of automated weaning under ASME V&V 40 and FDA guidelines.