Optimal interim analysis schedules that minimize expected sample size under the alternative are independent of effect size and endpoint type, and yield modest gains over equal spacing (up to 5.4% for O'Brien-Fleming designs).
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Optimal scheduling of interim analyses in group sequential trials
Optimal interim analysis schedules that minimize expected sample size under the alternative are independent of effect size and endpoint type, and yield modest gains over equal spacing (up to 5.4% for O'Brien-Fleming designs).