Biological ambiguity from temporally decoupled neurodegeneration and amyloid pathology creates one-to-many mappings that make MRI-to-amyloid PET synthesis intrinsically ill-posed, with performance restored by multimodal inputs.
Journal of the American Geriatrics Society69, 1774–1783 (7 2021)
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NeuroBridge integrates self-supervised MRI pretraining with hippocampal tasks and gated fusion to reach 88.17% AD vs. CN accuracy on ADNI and 82.78% on OASIS, claiming gains over single-task methods with cross-cohort generalization.
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When Brains Disagree: Biological Ambiguity Underlies the Challenge of Amyloid PET Synthesis from Structural MRI
Biological ambiguity from temporally decoupled neurodegeneration and amyloid pathology creates one-to-many mappings that make MRI-to-amyloid PET synthesis intrinsically ill-posed, with performance restored by multimodal inputs.
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NeuroBridge: Bridging Multi-Task MRI Knowledge for Neurodegenerative Disease Diagnosis
NeuroBridge integrates self-supervised MRI pretraining with hippocampal tasks and gated fusion to reach 88.17% AD vs. CN accuracy on ADNI and 82.78% on OASIS, claiming gains over single-task methods with cross-cohort generalization.