A two-step approach derives biomarker variability measures from mixed-effects residuals and includes them in standard joint models to estimate their association with time-to-event outcomes.
Prognostic significance of therapy-induced myelosuppression in newly diagnosed glioblas- toma.Neuro-Oncology, 24(9):1533–1545, 9 2022
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Joint modelling of time-dependent biomarker variability and time-to-event outcomes, a two-step approach
A two-step approach derives biomarker variability measures from mixed-effects residuals and includes them in standard joint models to estimate their association with time-to-event outcomes.