Critical points of a discrete network energy functional satisfy a generalized Murray's law with exponent (gamma+1)/2, and formal continuum analogues hold under extra regularity assumptions.
ODE and PDE based modeling of biological transportation networks
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abstract
We study the global existence of solutions of a discrete (ODE based) model on a graph describing the formation of biological transportation networks, introduced by Hu and Cai. We propose an adaptation of this model so that a macroscopic (PDE based) system can be obtained as its formal continuum limit. We prove the global existence of weak solutions of the macroscopic PDE model. Finally, we present results of numerical simulations of the discrete model, illustrating the convergence to steady states, their non-uniqueness as well as their dependence on initial data and model parameters.
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2019 1verdicts
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Murray's law for discrete and continuum models of biological networks
Critical points of a discrete network energy functional satisfy a generalized Murray's law with exponent (gamma+1)/2, and formal continuum analogues hold under extra regularity assumptions.