Maps the ICH E9(R1) estimand framework onto oncology randomized discontinuation trials, showing population and treatment attributes differ from traditional RCTs while intercurrent-event handling is similar when anchored at randomization.
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Estimands for Randomized Discontinuation Designs in Oncology
Maps the ICH E9(R1) estimand framework onto oncology randomized discontinuation trials, showing population and treatment attributes differ from traditional RCTs while intercurrent-event handling is similar when anchored at randomization.