The authors build a deep generative model that produces synthetically accessible ionizable lipids with synthesis paths, achieving an 83.4% ionizable lipid generation rate and demonstrating iterative optimization for mRNA transfection efficiency in HeLa cells.
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A Deep Generative Model for the Design of Synthesizable Ionizable Lipids
The authors build a deep generative model that produces synthetically accessible ionizable lipids with synthesis paths, achieving an 83.4% ionizable lipid generation rate and demonstrating iterative optimization for mRNA transfection efficiency in HeLa cells.