A two-stage intra-patient curve-free Bayesian decision-theoretic design for dose escalation under nonincreasing cycle-specific toxicity.
In this example, the investigational therapy is a GPC2 CAR T-cell product for pediatric and young adult patients with relapsed or refractory medulloblastoma (IND 31556)
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TWICEBEE: A Two-stage Intra-patient Curve-free Bayesian Decision-Theoretic Dose Escalation Design
A two-stage intra-patient curve-free Bayesian decision-theoretic design for dose escalation under nonincreasing cycle-specific toxicity.